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KMID : 0379520010170020097
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한국독성학회지
2001 Volume.17 No. 2 p.97 ~ p.106
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Effects of Gamma-Irradiated Korean Ginseng on Fertility and General Reproductive Toxicity in Rats
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Park Kui-Lea
Han Soon-Young
Kim Pan-Gyi
Lee Yu-Mi
Shin Jae-Hoo
Jang Seung-Jae
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Abstract
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Korean ginseng products have been fumigated with ethylene oxide (EO) for sterilization and prolongation of storage periods. However, there had been controversies indicating that the consumption of food treated with EO might cause harmful effects in human. Since, in Korea the use of EO gas for food treatment was banned in 1991. Since then, irradiation technique has been developed as an alternative. This study was carried out to investigate the effects of irradiated ginseng on fertility, and reproductive and developmental toxicity. Either EO gas fumigated or gamma-irradiated ginseng was administered to male rats by oral gavage for 63 days during the premating period. Female rats were administered from 14 days before mating to day 20 of gestation or to day 21 of lactation. The exposure amount of irradiation used was 5, 10 and 30 kGy, respectively. There were no treatment related changes of darns in clinical signs, and parturition. No treatment related changes in food consumption, body/organ weights, male/female reproductive and fertility performances were observed. F1 fetuses showed no external abnormality. Reflex/sensory junctions, physical/behavioral development, and reproductive performance of F1 rats were not adversary affected. The results of this study show that gamma-irradiated ginseng, up to 30 kGy, has no adverse effects on the fertility, reproduction and development in Wistar rats.
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KEYWORD
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Fertility, Reproductive & Developmental Toxicity, Korean ginseng, Gamma-irradiation, Rat
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